Reduction in activity by noxious chemical stimulation is ameliorated by immersion in analgesic drugs in zebrafish

@article{LopezLuna2017ReductionIA,
  title={Reduction in activity by noxious chemical stimulation is ameliorated by immersion in analgesic drugs in zebrafish},
  author={Javier Lopez-Luna and Qussay Al-Jubouri and Waleed Al-Nuaimy and Lynne U. Sneddon},
  journal={Journal of Experimental Biology},
  year={2017},
  volume={220},
  pages={1451 - 1458}
}
ABSTRACT Research has recently demonstrated that larval zebrafish show similar molecular responses to nociception to those of adults. Our study explored whether unprotected larval zebrafish exhibited altered behaviour after exposure to noxious chemicals and screened a range of analgesic drugs to determine their efficacy to reduce these responses. This approach aimed to validate larval zebrafish as a reliable replacement for adults as well as providing a high-throughput means of analysing… Expand
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