Reduction in absorption of gallium maltolate in adult horses following oral administration with food: chemistry and pharmacokinetics.
@article{Pollina2013ReductionIA, title={Reduction in absorption of gallium maltolate in adult horses following oral administration with food: chemistry and pharmacokinetics.}, author={G. Pollina and M. Pepe and A. Dean and V. Di Marco and D. Marton}, journal={Journal of veterinary pharmacology and therapeutics}, year={2013}, volume={36 5}, pages={ 456-61 } }
Gallium (Ga) is under study for the treatment of osteolytic disorders in equines. Previous studies indicate that oral gallium maltolate (GaM) would provide a higher bioavailability than oral Ga salts. However, oral administration to adult horses of 2 mg/kg of GaM, in the form of a solution mixed with food, did not lead to detectable Ga levels in plasma. Therefore, a study was performed to model the chemical behaviour of GaM in the digestive tract. The equilibrium formation constants for Ga(III… CONTINUE READING
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