Reduction in absorption of gallium maltolate in adult horses following oral administration with food: chemistry and pharmacokinetics.

@article{Pollina2013ReductionIA,
  title={Reduction in absorption of gallium maltolate in adult horses following oral administration with food: chemistry and pharmacokinetics.},
  author={G. Pollina and M. Pepe and A. Dean and V. Di Marco and D. Marton},
  journal={Journal of veterinary pharmacology and therapeutics},
  year={2013},
  volume={36 5},
  pages={
          456-61
        }
}
  • G. Pollina, M. Pepe, +2 authors D. Marton
  • Published 2013
  • Chemistry, Medicine
  • Journal of veterinary pharmacology and therapeutics
  • Gallium (Ga) is under study for the treatment of osteolytic disorders in equines. Previous studies indicate that oral gallium maltolate (GaM) would provide a higher bioavailability than oral Ga salts. However, oral administration to adult horses of 2 mg/kg of GaM, in the form of a solution mixed with food, did not lead to detectable Ga levels in plasma. Therefore, a study was performed to model the chemical behaviour of GaM in the digestive tract. The equilibrium formation constants for Ga(III… CONTINUE READING
    1 Citations

    References

    SHOWING 1-10 OF 18 REFERENCES
    Pharmacokinetics of an orally administered methylcellulose formulation of gallium maltolate in neonatal foals.
    • 18
    • PDF
    Tissue distribution of gallium following administration of the gallium-maltol complex in the rat: a model for an aluminium-maltol complex of neurotoxicological interest.
    • G. Farrar, A. P. Morton, J. Blair
    • Chemistry, Medicine
    • Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
    • 1988
    • 13
    Antimicrobial activity of gallium against virulent Rhodococcus equiin vitro and in vivo.
    • 70
    • PDF
    The effects of gallium nitrate on bone resorption.
    • 42
    Metal ion speciation in blood plasma: gallium-67-citrate and MRI contrast agents.
    • G. Jackson, M. Byrne
    • Chemistry, Medicine
    • Journal of nuclear medicine : official publication, Society of Nuclear Medicine
    • 1996
    • 54