• DOI:10.1111/JVP.12022
Corpus ID: 28526088

Reduction in absorption of gallium maltolate in adult horses following oral administration with food: chemistry and pharmacokinetics.

@article{Pollina2013ReductionIA,
  title={Reduction in absorption of gallium maltolate in adult horses following oral administration with food: chemistry and pharmacokinetics.},
  author={G. Pollina and M. Pepe and A. Dean and V. Di Marco and D. Marton},
  journal={Journal of veterinary pharmacology and therapeutics},
  year={2013},
  volume={36 5},
  pages={
          456-61
        }
}

G. Pollina, M. Pepe, +2 authors D. Marton

Published 2013

Chemistry, Medicine

Journal of veterinary pharmacology and therapeutics

Gallium (Ga) is under study for the treatment of osteolytic disorders in equines. Previous studies indicate that oral gallium maltolate (GaM) would provide a higher bioavailability than oral Ga salts. However, oral administration to adult horses of 2 mg/kg of GaM, in the form of a solution mixed with food, did not lead to detectable Ga levels in plasma. Therefore, a study was performed to model the chemical behaviour of GaM in the digestive tract. The equilibrium formation constants for Ga(III… CONTINUE READING

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