Reduction in DHA transport to the brain of mice expressing human APOE4 compared to APOE2.

@article{Vandal2014ReductionID,
  title={Reduction in DHA transport to the brain of mice expressing human APOE4 compared to APOE2.},
  author={Mil{\`e}ne Vandal and Wael Alata and Cyntia Tremblay and Christine Rioux-Perreault and Norman Salem and Fr{\'e}d{\'e}ric Calon and M{\'e}lanie Plourde},
  journal={Journal of neurochemistry},
  year={2014},
  volume={129 3},
  pages={516-26}
}
Benefits on cognition from docosahexaenoic acid (DHA, 22 : 6 n-3) intake are absent in humans carrying apolipoprotein E ε4 allele (APOE4), the most important genetic risk factor for Alzheimer's disease (AD). To test the hypothesis that carrying APOE4 impairs DHA distribution, we evaluated plasma and brain fatty acid profiles and uptake of [(14) C]-DHA using in situ cerebral perfusion through the blood-brain barrier in 4- and 13-month-old male and female APOE-targeted replacement mice (APOE2… CONTINUE READING
26 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 26 extracted citations

Similar Papers

Loading similar papers…