Reduction in CNS scar formation without concomitant increase in axon regeneration following treatment of adult rat brain with a combination of antibodies to TGFβ1 and β2

@article{Moon2001ReductionIC,
  title={Reduction in CNS scar formation without concomitant increase in axon regeneration following treatment of adult rat brain with a combination of antibodies to TGF$\beta$1 and $\beta$2},
  author={Lawrence David Falcon Moon and James W. Fawcett},
  journal={European Journal of Neuroscience},
  year={2001},
  volume={14}
}
  • L. Moon, J. Fawcett
  • Published 1 November 2001
  • Biology, Medicine
  • European Journal of Neuroscience
In this study we investigated whether CNS axons regenerate following attenuation of scar formation using a combination of antibodies against two isoforms of transforming growth factor beta (TGFβ). Anaesthetized adult rats were given unilateral mechanical lesions of the nigrostriatal tract. Implantation of transcranial cannulae allowed wounds to be treated with a combination of antibodies against TGFβ1 and TGFβ2 once daily for 10 days postaxotomy. Eleven days post‐transection brains from animals… 

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