Reduction in 2-deoxy-d-glucose analgesia following acute, but not chronic antidepressant treatment

@article{Bodnar1987ReductionI2,
  title={Reduction in 2-deoxy-d-glucose analgesia following acute, but not chronic antidepressant treatment},
  author={Richard J Bodnar and Maria-Teresa Romero and Benjamin Kest and Eric A. Stone},
  journal={Psychopharmacology},
  year={1987},
  volume={91},
  pages={207-208}
}
Acute, but not chronic, antidepressant treatment potentiates the analgesic responses following cold-water swims. The present study evaluated the effects of acute (10 mg/kg) and chronic (10 mg/kg, twice daily over 7 days) pretreatment with desipramine (DMI) upon the analgesic response following 2-deoxy-d-glucose (2dG) in rats as measured by the jump test. Acute, but not chronic, DMI pretreatment significantly reduced 2dG analgesia. These effects are discussed in terms of the heterogeneity of… CONTINUE READING

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