Reducing the risk of transmitting genital herpes: advances in understanding and therapy

@article{Leone2005ReducingTR,
  title={Reducing the risk of transmitting genital herpes: advances in understanding and therapy},
  author={Peter A. Leone},
  journal={Current Medical Research and Opinion},
  year={2005},
  volume={21},
  pages={1577 - 1582}
}
  • P. Leone
  • Published 2005
  • Medicine
  • Current Medical Research and Opinion
ABSTRACT Background: This review considers the epidemiology and impact of genital herpes, discusses how herpes simplex virus‐2 (HSV‐2) is transmitted, and reviews data on methods of reducing the risk of HSV transmission. Scope: Information for the paper was identified through multiple PubMed searches. Information in the section on interventions was identified through PubMed searches using several pairs of key words (herpes and transmission, herpes and treatment, herpes and antiviral, herpes and… Expand
GEITAL HERPES DISEASES: A OVERVIEW
TLDR
The standard, effective and specific treatment for genital herpes is antiviral therapy with drugs like Valacyclovir and Acyclovir combined with analgesics like Aspirin or Paracetamol. Expand
Herpes simplex virus infection in pregnancy - An update.
  • W. Hammad, J. Konje
  • Medicine
  • European journal of obstetrics, gynecology, and reproductive biology
  • 2021
TLDR
An overview of HSV in pregnancy, diagnosis and management especially around unique scenarios such as prelabour preterm rupture of fetal membranes and presentation with active disease in labour is provided. Expand
Famciclovir: a review of its use in herpes zoster and genital and orolabial herpes.
TLDR
Famciclovir is a well tolerated first-line option for the treatment of herpes zoster and the treatment and suppression of genital herpes, and is approved for the Treatment of recurrent orolabial herpes. Expand
Aetiology, diagnosis and therapyof sexually transmitted and allied infections—reflections on novel observations and current trends
  • P. Mårdh
  • Medicine
  • The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception
  • 2006
TLDR
The paper focuses on the discrepancy between the current high prevalence of diagnosed cases of some STIs and the relatively low number of complications and sequelae presently seen, in contrast to the comparatively high prevalence more commonly reported in the past. Expand
Is Famciclovir Superior to Valacyclovir as a Treatment for Recurrent Gential Herpes in Reducing Outbreak Duration and Frequency
TLDR
It is demonstrated that famciclovir is equally effective compared to valacyclovir, but does not appear to be superior in treating genital herpes, and the shorter dosing schedule of famcIClovir for herpes recurrence may provide a more convenient treatment option for some patients. Expand
Epidemiology of TORCH Infections and Understanding the Serology in Their Diagnosis
TLDR
The following article highlights the importance of serological tests for the diagnosis of TORCH infections and routine full screening of ‘TORCH panel’ is not recommended in low risk asymptomatic pregnant women. Expand
HIV, the Clustering of Sexually Transmitted Infections, and Sex Risk Among African American Women Who Use Drugs
TLDR
Several STIs, including HIV, seem to be endemic among black women who use drugs in this community, and in addition to the known geographical clustering of HIV andSTIs, STIs were also found to cluster at the individual level. Expand
Neonatal herpes disease following maternal antenatal antiviral suppressive therapy: a multicenter case series.
TLDR
Although maternal antiviral suppressive therapy for herpes simplex virus (HSV) disease in neonates whose mothers received suppressive acyclovir therapy is an increasingly wide practice, physicians caring for neonates should be aware that suppressive Therapy does not prevent neonatal HSV disease, which can have an atypical clinical presentation and drug resistance. Expand
Sexually Transmitted Infections (STIs) and the Developing Adolescent: Influences of and Strategies to Reduce STI Acquisition
TLDR
The sexually transmitted infection (STI) problem among adolescents is described, noting the disproportionately high rates of STIs reported each year among adolescents and the need to address the challenges and barriers associated with implementation of each strategy in order for them to be effective in reducing the STI rates among adolescents. Expand
Herpes Simplex Viruses: General Features
TLDR
Transmission, tissue tropism and the clinical features of infection including CNS disease are reviewed, as are pathogenicity and diagnosis, the mechanisms of latency and reactivation, host immune responses and immune evasion, therapy, vaccination and the use oncolytic HSV in cancer virotherapy. Expand
...
1
2
3
4
...

References

SHOWING 1-10 OF 41 REFERENCES
Once-daily valacyclovir to reduce the risk of transmission of genital herpes*
TLDR
Once-daily suppressive therapy with valacyclovir significantly reduces the risk of transmission of genital herpes among heterosexual, HSV-2-discordant couples. Expand
Genital herpes and public health: addressing a global problem.
TLDR
Doctors and patients must be aware of the subclinical presentation of genital herpes and the potential these patients have for transmitting HSV, and researchers must evaluate the performance of type-specific tests and strategies to prevent transmission. Expand
Suppression of Subclinical Shedding of Herpes Simplex Virus Type 2 with Acyclovir
TLDR
To determine whether acyclovir suppresses subclinical shedding of HSV-2 in the genital tract, a placebo-controlled, crossover trial of suppressive acyClovir therapy in women with recently acquired genital herpes is conducted. Expand
Improving the care of patients with genital herpes
TLDR
The majority of patients with genital herpes simplex virus infections have symptoms and signs unrecognised by either themselves or their clinicians, and oral antiviral treatment should be given for primary or first episode genital herpes. Expand
Advising patients with genital herpes
TLDR
The traditional view of genital herpes is that it is a low prevalence sexually transmitted disease, principally caused by herpes simplex virus type 2, but recent data from epidemiological, natural course, and antiviral studies suggest that this advice may be misleading. Expand
Effect of condoms on reducing the transmission of herpes simplex virus type 2 from men to women.
TLDR
Analysis of data from a randomized, double-blind, placebo-controlled trial of an ineffective candidate HSV-2 vaccine suggests that identification of discordant couples can reduce transmission of HSv-2, especially for heterosexual couples in which the male partner has HSV -2 infection. Expand
Recurrence Rates in Genital Herpes after Symptomatic First-Episode Infection
TLDR
The natural history of symptomatic recurrences in the complete population and in the subset of untreated patients is summarized. Expand
Risk factors for the sexual transmission of genital herpes.
TLDR
There was substantial risk for transmission; in 70% of patients, transmission appeared to result from sexual contact during periods of asymptomatic viral shedding, and the risk for acquisition of HSV was higher in women than men, and previous HSV type 1 infection appeared to reduce the risk in women. Expand
Frequency of Acquisition of First‐episode Genital Infection with Herpes Simplex Virus from Symptomatic and Asymptomatic Source Contacts
TLDR
Efforts to identify individuals with undiagnosed genital herpes and to instruct these individuals concerning the risk of disease transmission in the presence of lesions are needed if the rate of transmission is to be decreased; however, methods designed to deerease the rates of transmission by asymptomatic individuals must also be evaluated. Expand
Genital shedding of herpes simplex virus among men.
TLDR
The frequency of viral shedding in men with genital herpes appears comparable with that in women, and the shedding rate amongMen with genital HSV-2 was significantly higher than among men with herpes simplex virus type 2 infection. Expand
...
1
2
3
4
5
...