Reducing the risk of transmitting genital herpes: advances in understanding and therapy

  title={Reducing the risk of transmitting genital herpes: advances in understanding and therapy},
  author={Peter A. Leone},
  journal={Current Medical Research and Opinion},
  pages={1577 - 1582}
  • P. Leone
  • Published 5 September 2005
  • Medicine
  • Current Medical Research and Opinion
ABSTRACT Background: This review considers the epidemiology and impact of genital herpes, discusses how herpes simplex virus‐2 (HSV‐2) is transmitted, and reviews data on methods of reducing the risk of HSV transmission. Scope: Information for the paper was identified through multiple PubMed searches. Information in the section on interventions was identified through PubMed searches using several pairs of key words (herpes and transmission, herpes and treatment, herpes and antiviral, herpes and… 
The standard, effective and specific treatment for genital herpes is antiviral therapy with drugs like Valacyclovir and Acyclovir combined with analgesics like Aspirin or Paracetamol.
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The paper focuses on the discrepancy between the current high prevalence of diagnosed cases of some STIs and the relatively low number of complications and sequelae presently seen, in contrast to the comparatively high prevalence more commonly reported in the past.
Is Famciclovir Superior to Valacyclovir as a Treatment for Recurrent Gential Herpes in Reducing Outbreak Duration and Frequency
It is demonstrated that famciclovir is equally effective compared to valacyclovir, but does not appear to be superior in treating genital herpes, and the shorter dosing schedule of famcIClovir for herpes recurrence may provide a more convenient treatment option for some patients.
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Sexually Transmitted Infections (STIs) and the Developing Adolescent: Influences of and Strategies to Reduce STI Acquisition
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Once-daily valacyclovir to reduce the risk of transmission of genital herpes*
Once-daily suppressive therapy with valacyclovir significantly reduces the risk of transmission of genital herpes among heterosexual, HSV-2-discordant couples.
Genital herpes and public health: addressing a global problem.
Doctors and patients must be aware of the subclinical presentation of genital herpes and the potential these patients have for transmitting HSV, and researchers must evaluate the performance of type-specific tests and strategies to prevent transmission.
Suppression of Subclinical Shedding of Herpes Simplex Virus Type 2 with Acyclovir
To determine whether acyclovir suppresses subclinical shedding of HSV-2 in the genital tract, a placebo-controlled, crossover trial of suppressive acyClovir therapy in women with recently acquired genital herpes is conducted.
Improving the care of patients with genital herpes
The majority of patients with genital herpes simplex virus infections have symptoms and signs unrecognised by either themselves or their clinicians, and oral antiviral treatment should be given for primary or first episode genital herpes.
Advising patients with genital herpes
The traditional view of genital herpes is that it is a low prevalence sexually transmitted disease, principally caused by herpes simplex virus type 2, but recent data from epidemiological, natural course, and antiviral studies suggest that this advice may be misleading.
Effect of condoms on reducing the transmission of herpes simplex virus type 2 from men to women.
Analysis of data from a randomized, double-blind, placebo-controlled trial of an ineffective candidate HSV-2 vaccine suggests that identification of discordant couples can reduce transmission of HSv-2, especially for heterosexual couples in which the male partner has HSV -2 infection.
Recurrence Rates in Genital Herpes after Symptomatic First-Episode Infection
The natural history of symptomatic recurrences in the complete population and in the subset of untreated patients is summarized.
Risk factors for the sexual transmission of genital herpes.
There was substantial risk for transmission; in 70% of patients, transmission appeared to result from sexual contact during periods of asymptomatic viral shedding, and the risk for acquisition of HSV was higher in women than men, and previous HSV type 1 infection appeared to reduce the risk in women.
Frequency of Acquisition of First‐episode Genital Infection with Herpes Simplex Virus from Symptomatic and Asymptomatic Source Contacts
Efforts to identify individuals with undiagnosed genital herpes and to instruct these individuals concerning the risk of disease transmission in the presence of lesions are needed if the rate of transmission is to be decreased; however, methods designed to deerease the rates of transmission by asymptomatic individuals must also be evaluated.
Genital shedding of herpes simplex virus among men.
The frequency of viral shedding in men with genital herpes appears comparable with that in women, and the shedding rate amongMen with genital HSV-2 was significantly higher than among men with herpes simplex virus type 2 infection.