Reducing the number of rabbits in the Draize eye irritancy test: a statistical analysis of 155 studies conducted over 6 years.

@article{Talsma1988ReducingTN,
  title={Reducing the number of rabbits in the Draize eye irritancy test: a statistical analysis of 155 studies conducted over 6 years.},
  author={D M Talsma and Chet L. Leach and Nagi Hatoum and Robert D. Gibbons and J C Roger and Paul J Garvin},
  journal={Fundamental and applied toxicology : official journal of the Society of Toxicology},
  year={1988},
  volume={10 1},
  pages={146-53}
}
The Draize eye irritancy test in rabbits has been the focus of recent efforts to reduce the use of live animals in toxicity testing. A suitable alternative is not yet available; therefore, we studied the adequacy of reducing the number of rabbits used per test. Data generated from 6-rabbit eye irritation tests of 155 various materials were used to determine the ability of irritation scores from all possible combinations of 5-, 4-, 3-, or 2-rabbit subsets to predict the Draize score derived from… CONTINUE READING