Reducing sugars trigger oxidative modification and apoptosis in pancreatic beta-cells by provoking oxidative stress through the glycation reaction.

@article{Kaneto1996ReducingST,
  title={Reducing sugars trigger oxidative modification and apoptosis in pancreatic beta-cells by provoking oxidative stress through the glycation reaction.},
  author={Hideaki Kaneto and Junichi Fujii and Theingi Myint and Nobuko Miyazawa and Khan M Nasirul Islam and Yasushi Kawasaki and Kunihiro Suzuki and Masanori Nakamura and Hideki Tatsumi and Yoshimitsu Yamasaki and Naoyuki Taniguchi},
  journal={The Biochemical journal},
  year={1996},
  volume={320 ( Pt 3)},
  pages={855-63}
}
Several reducing sugars brought about apoptosis in isolated rat pancreatic islet cells and in the pancreatic beta-cell-derived cell line HIT. This apoptosis was characterized biochemically by inter-nucleosomal DNA cleavage and morphologically by nuclear shrinkage, chromatin condensation and apoptotic body formation. N-Acetyl-L-cysteine, an antioxidant, and aminoguanidine, an inhibitor of the glycation reaction, inhibited this apoptosis. We also showed directly that proteins in beta-cells were… CONTINUE READING
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Enzymology of Carbonyl Metabolism 2 (Flynn

  • S. Picard, S. Parthasarathy, J. Fruebis, J. L. Witztum
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