Reducing risk, improving outcomes: bioengineering less immunogenic protein therapeutics.

  title={Reducing risk, improving outcomes: bioengineering less immunogenic protein therapeutics.},
  author={Anne S De Groot and William Martin},
  journal={Clinical immunology},
  volume={131 2},
One of the great surprises of the biologics revolution has been the discovery that recombinant human proteins, including monoclonals of human origin, can cause immune responses when administered to immune-competent subjects. Preclinical and clinical evaluations of the potential immunogenicity of biologics have been primarily focused on humoral immune responses and as a result, the critical contribution of T cells to the development of anti-monoclonal antibodies (also known as anti-drug… CONTINUE READING


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