Reducing resistance allele formation in CRISPR gene drive.

  title={Reducing resistance allele formation in CRISPR gene drive.},
  author={Jackson Champer and Jingxian Liu and Suh Yeon Oh and Riona Reeves and Anisha Luthra and Nathan Oakes and Andrew G. Clark and Philipp W. Messer},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={115 21},
CRISPR homing gene drives can convert heterozygous cells with one copy of the drive allele into homozygotes, thereby enabling super-Mendelian inheritance. Such a mechanism could be used, for example, to rapidly disseminate a genetic payload in a population, promising effective strategies for the control of vector-borne diseases. However, all CRISPR homing gene drives studied in insects thus far have produced significant quantities of resistance alleles that would limit their spread. In this… CONTINUE READING

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