Reducing resistance allele formation in CRISPR gene drive.

@article{Champer2018ReducingRA,
  title={Reducing resistance allele formation in CRISPR gene drive.},
  author={Jackson Champer and Jingxian Liu and Suh Yeon Oh and Riona Reeves and Anisha Luthra and Nathan Oakes and Andrew G. Clark and Philipp W. Messer},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2018},
  volume={115 21},
  pages={
          5522-5527
        }
}
CRISPR homing gene drives can convert heterozygous cells with one copy of the drive allele into homozygotes, thereby enabling super-Mendelian inheritance. Such a mechanism could be used, for example, to rapidly disseminate a genetic payload in a population, promising effective strategies for the control of vector-borne diseases. However, all CRISPR homing gene drives studied in insects thus far have produced significant quantities of resistance alleles that would limit their spread. In this… CONTINUE READING

From This Paper

Topics from this paper.

Similar Papers

Loading similar papers…