Reducing prohibitin increases histone acetylation, and promotes androgen independence in prostate tumours by increasing androgen receptor activation by adrenal androgens

@inproceedings{Dart2012ReducingPI,
  title={Reducing prohibitin increases histone acetylation, and promotes androgen independence in prostate tumours by increasing androgen receptor activation by adrenal androgens},
  author={D Alwyn Dart and Greg N. Brooke and Ailsa Sita-Lumsden and Jonathan A. Waxman and Charlotte L Bevan},
  booktitle={Oncogene},
  year={2012}
}
Prostate cancers (PCs), initially responsive to anti-androgen therapies, often advance to a hormone-refractory ‘castrate-resistant’ PC (CRPC) stage. However, the androgen receptor (AR) pathway remains active and key for cell growth and gene expression within tumours, even in the apparent absence of hormone. Proposed mechanisms to explain progression, including AR amplification/mutation, are insufficient to completely explain CRPC and possible roles of AR cofactors such as prohibitin (PHB) are… CONTINUE READING
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