Reducing pain during propofol injection: the role of the solvent.

@article{Doenicke1996ReducingPD,
  title={Reducing pain during propofol injection: the role of the solvent.},
  author={Alfred W Doenicke and Michael F. Roizen and Jeus Rau and Wolfgang Kellermann and J{\"u}rgen Babl},
  journal={Anesthesia and analgesia},
  year={1996},
  volume={82 3},
  pages={472-4}
}
We hypothesized that the concentration of propofol in the aqueous phase may be the most important variable responsible for the pain experienced during injection of the drug. The concentration of propofol in the aqueous phase (18.57 micrograms/mL) can be decreased by increasing the fat content of the solvent. To test this hypothesis, 36 patients were randomly allocated to one of three groups, each receiving a different formulation of propofol. Group A received 20 mL of propofol alone in a… CONTINUE READING

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