Reducing immunosuppression preserves allograft function in presumptive and definitive polyomavirus-associated nephropathy.

@article{Schaub2010ReducingIP,
  title={Reducing immunosuppression preserves allograft function in presumptive and definitive polyomavirus-associated nephropathy.},
  author={S Schaub and Hans Hellmuth Hirsch and Michael Jan Dickenmann and Juerg Steiger and Michael J{\"o}rg Mihatsch and Helmut Hopfer and Michael J. Mayr},
  journal={American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons},
  year={2010},
  volume={10 12},
  pages={2615-23}
}
Early detection of polyomavirus BK (BKV) viremia and reduction of immunosuppression is recommended for preventing polyomavirus-associated nephropathy (PyVAN), but systematic histological evaluations were not performed in previous studies. We routinely screen for decoy cells and, if positive, measure plasma BKV-loads. In a cohort of 203 consecutive renal transplantations performed from 2005-2008, 38 patients (19%) developed BKV-viremia and were treated with reduction of immunosuppression. Based… CONTINUE READING
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