Reducing epitope spread during affinity maturation of an anti-ganglioside GD2 antibody.


Ab affinity maturation in vivo is always accompanied by negative selection to maintain Ag specificity. In contrast, in vitro affinity maturation can lead to epitope spread, resulting in loss of specificity. Anti-ganglioside-GD2 mAbs are clinically effective against neuroblastoma; pain and neuropathy are major side effects. We used structural relatives of… (More)
DOI: 10.4049/jimmunol.0901409


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