Reducing electrostatic charge on spacer devices and bronchodilator response.

  title={Reducing electrostatic charge on spacer devices and bronchodilator response.},
  author={Johannes H Wildhaber and Grant W. Waterer and Graham L Hall and Q A Summers},
  journal={British journal of clinical pharmacology},
  volume={50 3},
AIMS Plastic spacers are widely used with pressurized metered dose inhalers (pMDI). Reducing electrostatic charge by washing spacers with detergent has been shown to greatly improve in vitro and in vivo drug delivery. We assessed whether this finding is associated with an improved bronchodilator response in adult asthmatics. METHODS Twenty subjects (age 18-65 years) with a known bronchodilator response inhaled in random order salbutamol from a pMDI (Ventolin) through an untreated new spacer… CONTINUE READING
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