Reducing de novo donor-specific antibody levels during acute rejection diminishes renal allograft loss.

@article{Everly2009ReducingDN,
  title={Reducing de novo donor-specific antibody levels during acute rejection diminishes renal allograft loss.},
  author={Matthew J Everly and Jason J Everly and Lois J. Arend and Paul Brailey and Brian M Susskind and Amit Prakash Govil and Adele H Rike and Prabir Roy-Chaudhury and Gautham Mogilishetty and Rita R. Alloway and Amit Tevar and Ervin Steve Woodle},
  journal={American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons},
  year={2009},
  volume={9 5},
  pages={
          1063-71
        }
}
The effect of de novo DSA detected at the time of acute cellular rejection (ACR) and the response of DSA levels to rejection therapy on renal allograft survival were analyzed. Kidney transplant patients with acute rejection underwent DSA testing at rejection diagnosis with DSA levels quantified using Luminex single-antigen beads. Fifty-two patients experienced acute rejection with 16 (31%) testing positive for de novo DSA. Median follow-up was 27.0 +/- 17.4 months postacute rejection… CONTINUE READING

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