Reducing agents sensitize C-type nociceptors by relieving high-affinity zinc inhibition of T-type calcium channels.

@article{Nelson2007ReducingAS,
  title={Reducing agents sensitize C-type nociceptors by relieving high-affinity zinc inhibition of T-type calcium channels.},
  author={Michael T. Nelson and Jiwan Woo and Ho-Won Kang and Iuliia Vitko and Paula Q. Barrett and Edward Perez-Reyes and Jung-ha Lee and Hee-sup Shin and Slobodan M Todorovic},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2007},
  volume={27 31},
  pages={
          8250-60
        }
}
Recent studies have demonstrated an important role for T-type Ca2+ channels (T-channels) in controlling the excitability of peripheral pain-sensing neurons (nociceptors). However, the molecular mechanisms underlying the functions of T-channels in nociceptors are poorly understood. Here, we demonstrate that reducing agents as well as endogenous metal chelators sensitize C-type dorsal root ganglion nociceptors by chelating Zn2+ ions off specific extracellular histidine residues on Ca(v)3.2 T… CONTINUE READING

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