Reducing acetate excretion from E. coli K-12 by over-expressing the small RNA SgrS.

@article{Negrete2013ReducingAE,
  title={Reducing acetate excretion from E. coli K-12 by over-expressing the small RNA SgrS.},
  author={Alejandro Negrete and Nadim Majdalani and Je-Nie Phue and Joseph Shiloach},
  journal={New biotechnology},
  year={2013},
  volume={30 2},
  pages={269-73}
}
When exposed to the nonmetabolized glucose derivative alpha methyl glucoside (αMG), both Escherichia coli K-12 (JM109 and MG1655) and E. coli B (BL21) respond by reducing the concentration of the mRNA of the ptsG gene which is responsible for the biosynthesis of the glucose transporter EIICB(glu). This occurs through the over-expression of the noncoding small RNA SgrS, which interacts specifically with the mRNA of the ptsG gene and prevents its translation. However, when these bacteria are… CONTINUE READING

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