Reducing GABA receptors.

@article{Burt2003ReducingGR,
  title={Reducing GABA receptors.},
  author={David R. Burt},
  journal={Life sciences},
  year={2003},
  volume={73 14},
  pages={
          1741-58
        }
}
A number of important drugs act on GABA(A) receptors, pentameric GABA-gated chloride channels assembled from among 19 known subunits. In trying to discover the roles in the brain of the subunits and their combinations, with the goal of developing more selective drugs, one tool has been to reduce expression of the subunits and examine the functional consequences. After briefly examining the properties of GABA(A) receptors, this review surveys the means available for receptor subunit reduction… CONTINUE READING
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