Reduced voltage-dependent Ca2+ signaling in CA1 neurons after brief ischemia in gerbils.

@article{Connor1999ReducedVC,
  title={Reduced voltage-dependent Ca2+ signaling in CA1 neurons after brief ischemia in gerbils.},
  author={John A. Connor and Seddigheh Razani-Boroujerdi and Alexander Greenwood and Robert J Cormier and Jeffrey J Petrozzino and R. S. Lin},
  journal={Journal of neurophysiology},
  year={1999},
  volume={81 1},
  pages={299-306}
}
An initial overload of intracellular Ca2+ plays a critical role in the delayed death of hippocampal CA1 neurons that die a few days after transient ischemia. Without direct evidence, the prevailing hypothesis has been that Ca2+ overload may recur until cell death. Here, we report the first measurements of intracellular Ca2+ in living CA1 neurons within brain slices prepared 1, 2, and 3 days after transient (5 min) ischemia. With no sign of ongoing Ca2+ overload, voltage-dependent Ca2… CONTINUE READING