Reduced vitamin D in acute stroke.


BACKGROUND AND PURPOSE Stroke leads to a reduction in bone mineral density, altered calcium homeostasis, and an increase in hip fractures. Vitamin D deficiency is well documented in long-term stroke survivors and is associated with post-stroke hip fractures. Less is known regarding levels in acute stroke. METHODS We compared the serum 25-dihydroxyvitamin D levels of 44 patients admitted to an acute stroke unit with first-ever stroke with results obtained by measuring 96 healthy ambulant elderly subjects every 2 months for 1 year. Statistical Z scores of serum vitamin D were then calculated after seasonal adjustment for the month of sampling. RESULTS The mean Z score of vitamin D in acute stroke was -1.4 SD units (95% CI, -1.7, -1.1), with 77% of patients falling in the insufficient range. CONCLUSIONS Reduced vitamin D was identified in the majority of patients with acute stroke throughout the year and may have preceded stroke. Vitamin D is a potential risk marker for stroke, and the role of vitamin D repletion in enhancing musculoskeletal health after stroke needs to be explored.

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@article{Poole2006ReducedVD, title={Reduced vitamin D in acute stroke.}, author={Kenneth E. S. Poole and Nigel Loveridge and Peter Jay Barker and David John Halsall and Collette M Rose and Jonathan Reeve and Elizabeth A. Warburton}, journal={Stroke}, year={2006}, volume={37 1}, pages={243-5} }