Reduced upper airway nitric oxide in cystic fibrosis.

  title={Reduced upper airway nitric oxide in cystic fibrosis.},
  author={Ian M Balfour-Lynn and Aidan Laverty and Robert Dinwiddie},
  journal={Archives of disease in childhood},
  volume={75 4},
Nitric oxide (NO) produced within the respiratory tract is detectable in exhaled and nasal air. Its synthesis may be induced by inflammatory cytokines and reduced by glucocorticoids. Increased concentrations have been found in asthma and bronchiectasis. In this study, NO concentrations were determined in 63 children with cystic fibrosis, of whom 13 were on inhaled steroids (mean age 13.3 years) and 50 were not (mean age 12.3 years); 57 normal children (mean age 12.2 years) were also studied. NO… CONTINUE READING