Reduced type III neuregulin 1 expression does not modulate the behavioural sensitivity of mice to acute Δ9-tetrahydrocannabinol (D9-THC).

@article{Lloyd2018ReducedTI,
  title={Reduced type III neuregulin 1 expression does not modulate the behavioural sensitivity of mice to acute Δ9-tetrahydrocannabinol (D9-THC).},
  author={David Lloyd and David A Talmage and C Shannon Weickert and Tim Karl},
  journal={Pharmacology, biochemistry, and behavior},
  year={2018},
  volume={170},
  pages={64-70}
}
Mice with a mutation in the transmembrane domain of the schizophrenia risk gene, neuregulin 1 (Nrg1 TM HET), are more susceptible to the neuro-behavioural effects of Δ9-tetrahydrocannabinol (D9-THC), the principal psychoactive component in cannabis. However, NRG1 is transcriptionally complex with over 30 different isoforms, most of which carry a… CONTINUE READING