Reduced transferrin binding in Down syndrome: a route to senile plaque formation and dementia.

@article{Hodgkins1993ReducedTB,
  title={Reduced transferrin binding in Down syndrome: a route to senile plaque formation and dementia.},
  author={Peter Hodgkins and Verinder P Prasher and Glennys R. Farrar and Roy A. Armstrong and Steve Sturman and James D Corbett and Jerry A. Blair},
  journal={Neuroreport},
  year={1993},
  volume={5 1},
  pages={
          21-4
        }
}
Plasma transferrin binding in Down syndrome and Alzheimer's disease is significantly reduced compared with age matched controls and it was thought this may help elucidate a pathological time sequence for the onset of dementia in Down syndrome. In Down syndrome, there was a reduction in gallium and aluminium transferrin binding both with age and the onset of dementia. Non-transferrin bound gallium species were identified as non-transportable phosphate or silicate. Thus, the route of entry of… CONTINUE READING

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