Reduced transcription and progeny virus production of hepatitis B virus containing an 8-bp deletion in basic core promoter.

Abstract

We have demonstrated previously the presence of an 8-bp deletion mutant, spanning from nt. 1768 to nt. 1775 in the basic core promoter region of hepatitis B virus (HBV) in patients with anti-HBe positive asymptomatic phase before developing acute exacerbation after immunosuppressive treatment. The transcription and progeny virus production activities of the… (More)

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