Reduced tissue osmolarity increases TRPV4 expression and pro-inflammatory cytokines in intervertebral disc cells.

@article{Walter2016ReducedTO,
  title={Reduced tissue osmolarity increases TRPV4 expression and pro-inflammatory cytokines in intervertebral disc cells.},
  author={Benjamin A. Walter and Devina Purmessur and Aree Moon and Jessica Occhiogrosso and Damien M. Laudier and Andrew C. Hecht and James C Iatridis},
  journal={European cells & materials},
  year={2016},
  volume={32},
  pages={123-36}
}
The mechanical behaviour and cellular metabolism of intervertebral discs (IVDs) and articular cartilage are strongly influenced by their proteoglycan content and associated osmotic properties. This osmotic environment is a biophysical signal that changes with disease and may contribute to the elevated matrix breakdown and altered biologic response to… CONTINUE READING