Reduced telomere length in individuals with FMR1 premutations and full mutations.

  title={Reduced telomere length in individuals with FMR1 premutations and full mutations.},
  author={Edmund C Jenkins and Flora Tassone and Lingling Ye and Andr{\'e} T. Hoogeveen and William Ted Brown and Randi J. Hagerman and Paul J. Hagerman},
  journal={American journal of medical genetics. Part A},
  volume={158A 5},
We reported previously that 10 older men (66.4 ± 4.6 years) with premutation alleles (55-200 CGG repeats) of the FMR1 gene, with or without FXTAS, had decreased telomere length when compared to sex- and age-matched controls. Extending our use of light intensity measurements from a telomere probe hybridized to interphase preparations, we have now found shortened telomeres in 9 younger male premutation carriers (31.7 ± 17.6 years). We have also shown decreased telomere length in T lymphocytes… CONTINUE READING


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