Reduced telomere length in ataxia-telangiectasia fibroblasts.

  title={Reduced telomere length in ataxia-telangiectasia fibroblasts.},
  author={Shujuan J Xia and Masood A. Shammas and Robert Joseph Shmookler Reis},
  journal={Mutation research},
  volume={364 1},
Chromosomal instability with a high frequency of telomere fusion is characteristic of ataxia-telangiectasia cells both in vivo and in vitro. We have measured telomere length and found it to be consistently reduced in both diploid and SV40-transformed cells A-T fibroblasts, relative to control cells. We examined a few possible mechanisms which might account for telomeric length reduction, including telomerase activity in transformed cells and endogenous nuclease activities, but found no… CONTINUE READING

From This Paper

Figures, tables, results, connections, and topics extracted from this paper.
16 Extracted Citations
0 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 16 extracted citations

Similar Papers

Loading similar papers…