Reduced telomere DNA content is correlated with genomic instability and metastasis in invasive human breast carcinoma

Abstract

Telomere shortening leads to genomic instability and has been correlated with poor outcome in several types of cancer. A recently described, robust titration assay was used to quantify telomere DNA content in frozen and paraffin-embedded specimens of 49 invasive human breast carcinomas, including tumors with normal or abnormal contents of genomic DNA, which… (More)
DOI: 10.1023/A:1006128228761

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Cite this paper

@article{Griffith1999ReducedTD, title={Reduced telomere DNA content is correlated with genomic instability and metastasis in invasive human breast carcinoma}, author={Jeffrey K. Griffith and Jennifer E. Bryant and Colleen Augusta Fordyce and Frank D Gilliland and Nancy Elaine Joste and Robert K. Moyzis}, journal={Breast Cancer Research and Treatment}, year={1999}, volume={54}, pages={59-64} }