Reduced synaptophysin immunoreactivity in the dentate gyrus of prepulse inhibition-impaired isolation-reared rats

@article{Varty1999ReducedSI,
  title={Reduced synaptophysin immunoreactivity in the dentate gyrus of prepulse inhibition-impaired isolation-reared rats},
  author={Geoffrey B. Varty and Charles Alexander Marsden and Guy A Higgins},
  journal={Brain Research},
  year={1999},
  volume={824},
  pages={197-203}
}
Deficits in parvalbumin and calbindin immunoreactive cells in the hippocampus of isolation reared rats
TLDR
Findings demonstrate selective abnormalities of sub-populations of GABAergic interneurons in the hippocampus of isolation reared rats, which resemble the neuronal deficits seen in this region in schizophrenia.
Effect of isolation rearing on pre‐ and post‐synaptic serotonergic function in the rat dorsal hippocampus
TLDR
Isolation rearing in the rat results in hippocampal dysfunction, including reduced serotonergic and enhanced muscarinic activity of some neurones, which may in part underlie the behavioural consequences of isolation relevant to human developmental disorders.
Effect of isolation rearing on the expression of AMPA glutamate receptors in the hippocampal formation
TLDR
It is suggested that isolation rearing of rats from weaning induces changes on the expression of AMPA glutamate receptors in the hippocampus similar to those reported for postmortem human brains with schizophrenia.
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Social Isolation in the Rat Produces Developmentally Specific Deficits in Prepulse Inhibition of the Acoustic Startle Response Without Disrupting Latent Inhibition
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Social isolation led to deficits in PPI of the acoustic startle response that were specific to isolation-reared animals, and the utility of social isolation model as a nonlesion, nonpharmacologic means of perturbing ventral striatal DA function.
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Results demonstrate experience-dependent changes in neural structure in the striatum and suggest that the mechanisms for information storage in response to experience may be more widespread in the forebrain than previously believed.
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