Reduced susceptibility to scrapie in mice after steroid administration

@article{Outram1974ReducedST,
  title={Reduced susceptibility to scrapie in mice after steroid administration},
  author={G W Outram and Alex G. Dickinson and Hugh Fraser},
  journal={Nature},
  year={1974},
  volume={249},
  pages={855-856}
}
ANIMALS deficient in lymphoreticular function either by age, genotype or immunosuppression are more susceptible to infection by most known pathogens mainly on account of their depressed immunological responses. An intact lymphoreticular system (LRS), however, can itself contribute to disease by various mechanisms including; providing sites for multiplication1, producing infectious complexes2 and precipitating autoaggressive accompaniments and sequalae3. It is possible that a special class of… CONTINUE READING

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