Reduced suppression of CO2-induced ventilatory stimulation by endomorphins relative to morphine.

@article{Czapla2005ReducedSO,
  title={Reduced suppression of CO2-induced ventilatory stimulation by endomorphins relative to morphine.},
  author={Marc A Czapla and James E. Zadina},
  journal={Brain research},
  year={2005},
  volume={1059 2},
  pages={159-66}
}
Opioids are among the most effective analgesics, but a major limitation for their therapeutic usefulness is their induction of respiratory depression. Endomorphin-1 (EM1), in contrast to several other mu opioids, exhibits a threshold for respiratory depression that is well above its threshold for analgesia. Its effect on sensitivity to CO(2), however, remains unknown. Minute ventilation (V(E)) in 2, 4, and 6% CO(2) was measured before and after systemic administration of EM1, endomorphin-2 (EM2… CONTINUE READING