Reduced supply of monocyte-derived macrophages leads to a transition from nodular to diffuse lesions and tissue cell activation in silica-induced pulmonary fibrosis in mice.

@article{Shichino2015ReducedSO,
  title={Reduced supply of monocyte-derived macrophages leads to a transition from nodular to diffuse lesions and tissue cell activation in silica-induced pulmonary fibrosis in mice.},
  author={Shigeyuki Shichino and Jun Abe and Satoshi Ueha and Mikiya Otsuji and Tatsuya Tsukui and Mizuha Kosugi-Kanaya and Francis H W Shand and Shin-ichi Hashimoto and Hiroshi I Suzuki and Teppei Morikawa and Yutaka Inagaki and Kouji Matsushima},
  journal={The American journal of pathology},
  year={2015},
  volume={185 11},
  pages={2923-38}
}
Pulmonary fibrosis (PF) is an intractable disorder with a poor prognosis. Lung macrophages have been reported to regulate both progression and remission of bleomycin-induced diffuse PF. However, it remains unclear how macrophages contribute to silica-induced progressive nodular PF and the associated tissue cell responses in vivo. We found that lack of monocyte-derived macrophages results in the formation of diffuse PF after silica instillation. We found that the proportion and the number of… CONTINUE READING