Reduced striatal dopamine underlies the attention system dysfunction in neurofibromatosis-1 mutant mice.

Abstract

Learning and behavioral abnormalities are among the most common clinical problems in children with the neurofibromatosis-1 (NF1) inherited cancer syndrome. Recent studies using Nf1 genetically engineered mice (GEM) have been instructive for partly elucidating the cellular and molecular defects underlying these cognitive deficits; however, no current model… (More)
DOI: 10.1093/hmg/ddq382

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