Reduced striatal dopamine D1-D2 receptor heteromer expression and behavioural subsensitivity in juvenile rats.

@article{Perreault2012ReducedSD,
  title={Reduced striatal dopamine D1-D2 receptor heteromer expression and behavioural subsensitivity in juvenile rats.},
  author={Melissa L. Perreault and Ahmed Hasbi and Mohammed Alijaniaram and Brian F O'dowd and Susan R. George},
  journal={Neuroscience},
  year={2012},
  volume={225},
  pages={130-9}
}
In adult rat striatum the dopamine D1-D2 receptor heteromer is expressed selectively in a subset of medium spiny neurons (MSNs) that coexpress the dopamine D1 and D2 receptors (D1R and D2R) as well as dynorphin (DYN) and enkephalin (ENK), with higher coexpression in nucleus accumbens (NAc) and much lower in the caudate putamen (CP). In the present study we showed that in neonatal striatal cultured neurons >90% exhibited the D1R/D2R-DYN/ENK phenotype. Similarly, in the striatum of juvenile rats… CONTINUE READING

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In adult rat striatum the dopamine D1-D2 receptor heteromer is expressed selectively in a subset of medium spiny neurons ( MSNs ) that coexpress the dopamine D1 and D2 receptors ( D1R and D2R ) as well as dynorphin ( DYN ) and enkephalin ( ENK ) , with higher coexpression in nucleus accumbens ( NAc ) and much lower in the caudate putamen ( CP ) .
In adult rat striatum the dopamine D1-D2 receptor heteromer is expressed selectively in a subset of medium spiny neurons ( MSNs ) that coexpress the dopamine D1 and D2 receptors ( D1R and D2R ) as well as dynorphin ( DYN ) and enkephalin ( ENK ) , with higher coexpression in nucleus accumbens ( NAc ) and much lower in the caudate putamen ( CP ) .
Given the proposed role of D1R / D2R - coexpressing MSNs in the regulation of thalamic output , and the recent discovery that these MSNs exhibit both inhibitory and excitatory capabilities , these findings suggest that the functional regulation of neurotransmission by the dopamine D1-D2 receptor heteromer within the juvenile striatum may be significantly different than in the adult .
In adult rat striatum the dopamine D1-D2 receptor heteromer is expressed selectively in a subset of medium spiny neurons ( MSNs ) that coexpress the dopamine D1 and D2 receptors ( D1R and D2R ) as well as dynorphin ( DYN ) and enkephalin ( ENK ) , with higher coexpression in nucleus accumbens ( NAc ) and much lower in the caudate putamen ( CP ) .
In adult rat striatum the dopamine D1-D2 receptor heteromer is expressed selectively in a subset of medium spiny neurons ( MSNs ) that coexpress the dopamine D1 and D2 receptors ( D1R and D2R ) as well as dynorphin ( DYN ) and enkephalin ( ENK ) , with higher coexpression in nucleus accumbens ( NAc ) and much lower in the caudate putamen ( CP ) .
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