Reduced store-operated Ca2+ entry in pulmonary endothelial cells from chronically hypoxic rats.

@article{Paffett2007ReducedSC,
  title={Reduced store-operated Ca2+ entry in pulmonary endothelial cells from chronically hypoxic rats.},
  author={Michael L. Paffett and Jay S Naik and Thomas C. Resta and Benjimen R. Walker},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2007},
  volume={293 5},
  pages={L1135-42}
}
Chronic hypoxia (CH)-induced pulmonary hypertension may influence basal endothelial cell (EC) intracellular Ca(2+) concentration ([Ca(2+)](i)). We hypothesized that CH decreases EC [Ca(2+)](i) associated with membrane depolarization and reduced Ca(2+) entry. To test this hypothesis, we assessed 1) basal endothelial Ca(2+) in pressurized pulmonary arteries and freshly isolated ECs, 2) EC membrane potential (E(m)), 3) store-operated Ca(2+) current (I(SOC)), and 4) store-operated Ca(2+) (SOC… CONTINUE READING