Reduced spontaneous activity of mice defective in the epsilon 4 subunit of the NMDA receptor channel.

@article{Ikeda1995ReducedSA,
  title={Reduced spontaneous activity of mice defective in the epsilon 4 subunit of the NMDA receptor channel.},
  author={Kiyoshi Ikeda and Kazuaki Araki and Chitoshi Takayama and Yoshiro Inoue and Takeshi Yagi and Shinichi Aizawa and Masayoshi Mishina},
  journal={Brain research. Molecular brain research},
  year={1995},
  volume={33 1},
  pages={61-71}
}
In an attempt to examine the functional significance of the molecular diversity of the N-methyl-D-aspartate (NMDA) receptor channel, we generated mutant mice defective in the epsilon 4 subunit by gene targeting technique. The epsilon 4 subunit mutant mice grew and mated normally. No epsilon 4 subunit protein was detected in the homozygous mutant mice, and the amount of the epsilon 4 subunit protein of 155 kDa was reduced in the heterozygous mice. The expressions of the other NMDA receptor… CONTINUE READING

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