Reduced skin tumor development in cyclin D1-deficient mice highlights the oncogenic ras pathway in vivo.

@article{Robles1998ReducedST,
  title={Reduced skin tumor development in cyclin D1-deficient mice highlights the oncogenic ras pathway in vivo.},
  author={Ana I Robles and Marcelo L. Rodriguez-Puebla and Adam B. Glick and Carol S. Trempus and Laura Hansen and Peter Sicinski and Raymond W. Tennant and Robert A Weinberg and Stuart H. Yuspa and Claudio J. Conti},
  journal={Genes & development},
  year={1998},
  volume={12 16},
  pages={2469-74}
}
Cyclin D1 is part of a cell cycle control node consistently deregulated in most human cancers. However, studies with cyclin D1-null mice indicate that it is dispensable for normal mouse development as well as cell growth in culture. Here, we provide evidence that ras-mediated tumorigenesis depends on signaling pathways that act preferentially through cyclin D1. Cyclin D1 expression and the activity of its associated kinase are up-regulated in keratinocytes in response to oncogenic ras… CONTINUE READING