Reduced serum hepcidin levels in patients with chronic hepatitis C.

@article{Girelli2009ReducedSH,
  title={Reduced serum hepcidin levels in patients with chronic hepatitis C.},
  author={Domenico Girelli and Michela Pasino and Julia B. Goodnough and Elizabeta Nemeth and Maria Guido and Annalisa Castagna and Fabiana Busti and Natascia Campostrini and Nicola I Martinelli and Italo Vantini and Roberto Corrocher and Tomas Ganz and Giovanna Fattovich},
  journal={Journal of hepatology},
  year={2009},
  volume={51 5},
  pages={845-52}
}
BACKGROUND/AIMS Patients with chronic hepatitis C (CHC) often have increased liver iron, a condition associated with reduced sustained response to antiviral therapy, more rapid progression to cirrhosis, and development of hepatocellular carcinoma. The hepatic hormone hepcidin is the major regulator of iron metabolism and inhibits iron absorption and recycling from erythrophagocytosis. Hepcidin decrease is a possible pathophysiological mechanism of iron overload in CHC, but studies in humans… CONTINUE READING

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