Reduced sample number for calculation of insulin sensitivity and glucose effectiveness from the minimal model. Suitability for use in population studies.

@article{Steil1993ReducedSN,
  title={Reduced sample number for calculation of insulin sensitivity and glucose effectiveness from the minimal model. Suitability for use in population studies.},
  author={Garry M. Steil and Aa. V{\'o}lund and Steven E Kahn and Richard N Bergman},
  journal={Diabetes},
  year={1993},
  volume={42 2},
  pages={250-6}
}
The FSIGT has been extensively applied to the minimal model of glucose kinetics to obtain noninvasive measures of Sl. The protocol has been modified by the addition of a bolus tolbutamide or insulin injection 20 min after glucose. Although the modified protocol has improved the Sl estimate, the method still requires a relatively large number of samples (n = 30). To reduce the total number of samples, we choose a sample schedule that minimizes the variance of the parameter estimates and the… CONTINUE READING

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