Reduced repair of the oxidative 8-oxoguanine DNA damage and risk of head and neck cancer.

@article{PazElizur2006ReducedRO,
  title={Reduced repair of the oxidative 8-oxoguanine DNA damage and risk of head and neck cancer.},
  author={Tamar Paz-Elizur and Rami Ben-Yosef and Dalia Elinger and Akiva Vexler and Meir Krupsky and Alain Berrebi and Adi Shani and Edna Schechtman and Laurence Freedman and Zvi Livneh},
  journal={Cancer research},
  year={2006},
  volume={66 24},
  pages={11683-9}
}
An increasing number of studies indicate that reduced DNA-repair capacity is associated with increased cancer risk. Using a functional assay for the removal of the oxidative DNA lesion 8-oxoguanine by the DNA-repair enzyme 8-oxoguanine DNA glycosylase 1 (OGG1), we have previously shown that reduced OGG activity is a risk factor in lung cancer. Here, we report that OGG activity in peripheral blood mononuclear cells from 37 cases with squamous cell carcinoma of the head and neck (SCCHN) was… CONTINUE READING
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