Reduced regulatory T cells are associated with higher levels of Th1/TH17 cytokines and activated MAPK in type 1 bipolar disorder.

@article{Prado2013ReducedRT,
  title={Reduced regulatory T cells are associated with higher levels of Th1/TH17 cytokines and activated MAPK in type 1 bipolar disorder.},
  author={Carine Hartmann do Prado and Lucas Rizzo and Andr{\'e}a Wieck and Rodrigo Pestana Lopes and Ant{\^o}nio L{\'u}cio Teixeira and Rodrigo Grassi-Oliveira and Mois{\'e}s Evandro Bauer},
  journal={Psychoneuroendocrinology},
  year={2013},
  volume={38 5},
  pages={667-76}
}
Bipolar disorder (BD) has been associated with an immunologic imbalance shown by increased peripheral inflammatory markers. The underlying mechanisms of this phenomenon may include changes in circulating cells and differential activation of mitogen-activated protein kinases (MAPKs). Twenty-seven euthymic female subjects with BD type I (all medicated) and 24 age- and sex-matched controls were recruited in this study. Lymphocytes were isolated and stimulated in vitro to assess Th1/Th17/Th2… CONTINUE READING