Reduced rate of adenosine triphosphate synthesis by in vivo 31P nuclear magnetic resonance spectroscopy and downregulation of PGC-1beta in distal skeletal muscle following burn.

@article{Tzika2008ReducedRO,
  title={Reduced rate of adenosine triphosphate synthesis by in vivo 31P nuclear magnetic resonance spectroscopy and downregulation of PGC-1beta in distal skeletal muscle following burn.},
  author={Aria Tzika and Dionyssios Mintzopoulos and Katie E Padfield and Julie Wilhelmy and Michael N. Mindrinos and Hongue Yu and Haihui Cao and Qunhao Zhang and L. G. Astrakas and Jiangwen Zhang and Yong-ming Yu and Laurence G Rahme and Ronald G. Tompkins},
  journal={International journal of molecular medicine},
  year={2008},
  volume={21 2},
  pages={201-8}
}
Using a mouse model of burn trauma, we tested the hypothesis that severe burn trauma corresponding to 30% of total body surface area (TBSA) causes reduction in adenosine triphosphate (ATP) synthesis in distal skeletal muscle. We employed in vivo 31P nuclear magnetic resonance (NMR) in intact mice to assess the rate of ATP synthesis, and characterized the concomitant gene expression patterns in skeletal muscle in burned (30% TBSA) versus control mice. Our NMR results showed a significantly… CONTINUE READING

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