Reduced protective efficacy of a blood-stage malaria vaccine by concurrent nematode infection.

@article{Su2006ReducedPE,
  title={Reduced protective efficacy of a blood-stage malaria vaccine by concurrent nematode infection.},
  author={Zhong Yuan Su and M. Garcia Segura and Mary M Stevenson},
  journal={Infection and immunity},
  year={2006},
  volume={74 4},
  pages={2138-44}
}
Helminth infections, which are prevalent in areas where malaria is endemic, have been shown to modulate immune responses to unrelated pathogens and have been implicated in poor efficacy of malaria vaccines in humans. We established a murine coinfection model involving blood-stage Plasmodium chabaudi AS malaria and a gastrointestinal nematode, Heligmosomoides polygyrus, to investigate the impact of nematode infection on the protective efficacy of a malaria vaccine. C57BL/6 mice immunized with… CONTINUE READING