Reduced prostate branching morphogenesis in stromal fibroblast, but not in epithelial, estrogen receptor α knockout mice.

@article{Chen2012ReducedPB,
  title={Reduced prostate branching morphogenesis in stromal fibroblast, but not in epithelial, estrogen receptor α knockout mice.},
  author={Ming Chen and Chiuan-Ren Yeh and C R Shyr and Hsiu-Hsia Lin and Jun Da and Shuyuan Yeh},
  journal={Asian journal of andrology},
  year={2012},
  volume={14 4},
  pages={546-55}
}
Early studies suggested that estrogen receptor alpha (ERα) is involved in estrogen-mediated imprinting effects in prostate development. We recently reported a more complete ERα knockout (KO) mouse model via mating β-actin Cre transgenic mice with floxed ERα mice. These ACTB-ERαKO male mice showed defects in prostatic branching morphogenesis, which demonstrates that ERα is necessary to maintain proliferative events in the prostate. However, within which prostate cell type ERα exerts those… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 53 references

epithelial development and IGF - 1 signal in mice lacking the androgen receptor in stromal smooth muscle cells

  • Z Weihua, S Makela, LC Andersson, S Salmi, S Saji
  • 2011

epithelial development in mice lacking the androgen receptor in stromal fibroblasts

  • S Yu, C Zhang, CC Lin, Y Niu, KP Lai
  • 2011

Similar Papers

Loading similar papers…