Reduced production rates of testosterone and dihydrotestosterone in healthy men treated with rosiglitazone.

@article{Vierhapper2003ReducedPR,
  title={Reduced production rates of testosterone and dihydrotestosterone in healthy men treated with rosiglitazone.},
  author={Heinrich Vierhapper and Peter Nowotny and Werner Waldh{\"a}usl},
  journal={Metabolism: clinical and experimental},
  year={2003},
  volume={52 2},
  pages={230-2}
}
The effect of the thiazolidinedione, rosiglitazone (8 mg/d for 7 days), on the production rates of testosterone (T), dihydrotestosterone (DHT), and cortisol (F) was studied in healthy men (n = 10) using the stable isotope dilution technique and mass spectrometry. Treatment with rosiglitazone resulted in a decrease in the production rates of T from, basal, 318 +/- 62 microg/h to 272 +/- 72 microg/h (P <.05). Production rates of DHT fell from, basal, 21 +/- 6 microg/h to 17 +/- 5 microg/h (P <.05… CONTINUE READING

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