Reduced production of IL-12 and IL-12-dependent IFN-gamma release in patients with allergic asthma.

@article{Kraan1997ReducedPO,
  title={Reduced production of IL-12 and IL-12-dependent IFN-gamma release in patients with allergic asthma.},
  author={Tineke C. T. M. van der Pouw Kraan and Leonie C. M. Boeije and Els R de Groot and Steven O. Stapel and Alies Snijders and Martien L. Kapsenberg and Jaring S van der Zee and Lucien A. Aarden},
  journal={Journal of immunology},
  year={1997},
  volume={158 11},
  pages={5560-5}
}
In atopic patients, allergen-specific T cells have acquired the Th2 phenotype, which is considered to be responsible for the class switch to IgE Ab formation. Because IL-12 is a key cytokine for the induction of Th1 responses, a reduced capacity to produce this cytokine could lead to aberrant Th2 development. Therefore, we examined the production of IL-12 in whole blood cultures from patients with allergic asthma (n = 15) in comparison with nonatopic control subjects (n = 15) to different… CONTINUE READING

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