Reduced prepulse inhibition in unaffected siblings of schizophrenia patients.

@article{Kumari2005ReducedPI,
  title={Reduced prepulse inhibition in unaffected siblings of schizophrenia patients.},
  author={Veena Kumari and Mrigen Das and Elizabeth Shobha Zachariah and Ulrich Ettinger and Tonmoy Sharma},
  journal={Psychophysiology},
  year={2005},
  volume={42 5},
  pages={588-94}
}
We investigated whether prepulse inhibition of the startle response is reduced in siblings of schizophrenia patients compared to age- and sex-matched healthy controls. Nineteen unaffected biological siblings and 19 controls were assessed on prepulse inhibition by monaural and binaural acoustic prepulse stimuli, with the startle stimuli always presented binaurally. There was significantly less prepulse inhibition in siblings, compared to controls, with binaural prepulse stimuli, as also seen… CONTINUE READING