Reduced postischemic macrophage infiltration and interstitial fibrosis in osteopontin knockout mice.

@article{Persy2003ReducedPM,
  title={Reduced postischemic macrophage infiltration and interstitial fibrosis in osteopontin knockout mice.},
  author={Veerle P Persy and A. Verhulst and Dirk K Ysebaert and Kathleen E De Greef and Marc E. De Broe},
  journal={Kidney international},
  year={2003},
  volume={63 2},
  pages={543-53}
}
BACKGROUND Osteopontin (OPN) is a phosphoprotein that is up-regulated in several experimental models of renal disease, including ischemia/reperfusion injury. OPN has been described as a macrophage chemoattractant, may serve as a survival factor for tubular cells, and is implicated in the development of tubulointerstitial fibrosis. However, the precise role of this protein in renal pathophysiology remains unclear. METHODS OPN knockout and wild-type mice were subjected to 30 minutes of warm… CONTINUE READING

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