Reduced platelet vesicular monoamine transporter density in smoking schizophrenia patients.

@article{Schwartz2005ReducedPV,
  title={Reduced platelet vesicular monoamine transporter density in smoking schizophrenia patients.},
  author={Karin Schwartz and Iulian Iancu and Rafael Stryjer and Joseph Chelben and Moshe Kotler and Abraham Weizman and Moshe Rehavi},
  journal={European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology},
  year={2005},
  volume={15 5},
  pages={557-61}
}
Brain vesicular monoamine transporter 2 (VMAT2) has a critical role in the regulation of monoaminergic neurotransmission. In our previous study we have found decreased platelet VMAT2 density in healthy habitual smokers. Schizophrenia is associated with high rate of cigarette smoking. In the present study we assessed platelet VMAT2 pharmacodynamic characteristics in a population of medicated schizophrenia patients (n=36) comparing smokers (n=23) vs. non-smokers (n=13). A significant decrease in… CONTINUE READING

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